Phosphorus oxychloride → HCID 15746236, compound

HRID 1492178Notes

Reaction equation

HRID 1492178 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH3:13])[C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.P(Cl)(Cl)(Cl)=O>C1C=CC=CC=1>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH3:13])[C:9]1=[N:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 7357562-MorpholinoanilineHCID 113099963-Methyl-1-(phenylmethyl)-2-pyrrolidinone

Product 1

HCID 15746236HCID 15746236, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

In a similar manner to that described in Example 1, 1-benzyl-3-methyl-2-pyrrolidone (14.17 g) in benzene (80 ml) was reacted with 4-(2-aminophenyl)morpholine (8.9 g) in benzene (30 ml) in the presence of phosphorus oxychloride (6.86 ml) for 24 hours at 70° C. to give 4-[2-(1-benzyl-3-methyl-2-pyrrolidinylideneamino)phenyl]morpholine (m.p. 96°-97° C.) which was recrystallised from hexane.

Sources & evidence

ORD record
ord-4ebc10d83bd54922bfdff6c2eba012cd
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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