Acetonitrile → HCID 178465569, compound

HRID 1492180Notes

Reaction equation

HRID 1492180 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[Cl-].[Al+3].[Cl-].[Cl-].[C:18](#[N:20])[CH3:19]>>[O:11]1[CH2:12][CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:18](=[NH:20])[CH3:19])[CH2:9][CH2:10]1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 7357562-MorpholinoanilineHCID 6451240Aluminum(III) Chloride

Product 1

HCID 178465569HCID 178465569, compound

Procedure

A mixture of 4-(2-aminophenyl)morpholine (5.3 g), acetonitrile (4.52 ml) and anhydrous aluminium chloride (12 g) was heated at 160°-170° C. for 4 hours to yield N-(2-morpholinophenyl)acetamidine (m.p. 140°-141° C.) which was recrystallised from hexane.

Workup

  1. temperaturewas heated at 160°-170° C. for 4 hours

Sources & evidence

ORD record
ord-ca242a02a8d84b9eb7dce2e6d78885e1
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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