Acetonitrile → HCID 178465572, compound

HRID 1492181Notes

Reaction equation

HRID 1492181 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1.[Cl-].[Al+3].[Cl-].[Cl-].[C:19](#[N:21])[CH3:20]>>[CH3:8][C:6]1[CH:5]=[CH:4][C:3]([N:9]2[CH2:10][CH2:11][O:12][CH2:13][CH2:14]2)=[C:2]([NH:1][C:19](=[NH:21])[CH3:20])[CH:7]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 6451240Aluminum(III) ChlorideHCID 18952141HCID 18952141, compound

Product 1

HCID 178465572HCID 178465572, compound

Procedure

A mixture of 4-(2-amino-4-methylphenyl)morpholine (5.76 g), acetonitrile (3.5 g) and anhydrous aluminium chloride (12 g) was heated at 160°-170° C. for 5 hours to yield N-(5-methyl-2-morpholinophenyl)acetamidine (m.p. 121° C.) which was recrystallised from hexane.

Workup

  1. temperaturewas heated at 160°-170° C. for 5 hours

Sources & evidence

ORD record
ord-d75ce135e40d41ec864e8dbdf53216e0
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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