Pivalonitrile → HCID 178446834, compound

HRID 1492189Notes

Reaction equation

HRID 1492189 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[C:14](#[N:19])[C:15]([CH3:18])([CH3:17])[CH3:16].[Cl-].[Al+3].[Cl-].[Cl-]>>[O:11]1[CH2:12][CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:14](=[NH:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:9][CH2:10]1

Participants

4

Reactant 3

HCID 12416PivalonitrileHCID 7357562-MorpholinoanilineHCID 6451240Aluminum(III) Chloride

Product 1

HCID 178446834HCID 178446834, compound

Procedure

A mixture of 4-(2-aminophenyl)morpholine (3.56 g), pivalonitrile (5 g) and anhydrous aluminium chloride (8 g) was heated at 160°-170° C. for six hours to yield N-(2-morpholinophenyl)pivalamidine (m.p. 126° C.) which was recrystallised from hexane and converted into its monofumarate salt (m.p. 211° C.) which was recrystallised from methanol.

Workup

  1. temperaturewas heated at 160°-170° C. for six hours

Sources & evidence

ORD record
ord-68e86047f21b43d3b9078bafb8a10ed1
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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