Phosphorus oxychloride → HCID 15746403, compound

HRID 1492201Notes

Reaction equation

HRID 1492201 reaction equation
[CH2:1]([N:5]([CH3:11])[C:6](=O)[N:7]([CH3:9])[CH3:8])[CH2:2][CH2:3][CH3:4].[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.P(Cl)(Cl)(Cl)=O>C1C=CC=CC=1>[CH2:1]([N:5]([CH3:11])[C:6]([N:7]([CH3:9])[CH3:8])=[N:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 7357562-MorpholinoanilineHCID 22952135HCID 22952135, compound

Product 1

HCID 15746403HCID 15746403, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

Reaction of 3-n-butyl-1,1,3-trimethylurea (7 g) in benzene (60 ml) with 4-(2-aminophenyl)morpholine (7.2 g) in benzene (30 ml) in the presence of phosphorus oxychloride (4 ml) for 18 hours at 80°-85° C. gave 1-n-butyl-2-(2-morpholinophenyl)-1,3,3-trimethyl guanidine (bp. 162°-163° C. at 0.7 mm Hg).

Sources & evidence

ORD record
ord-6b4e42bd706e4b67bcc5ba7516d08319
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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