HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → HCID 15746466, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-Piperidinecarboxamide, N,N-dimethyl- | HCID 99268 | — |
| Reactant | HCID 13479496 | HCID 13479496 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 15746466 | HCID 15746466 | — |
Reaction Steps
Reaction of 1-dimethylcarbamoylpiperidine (3.7 g) in benzene (25 ml) with 4-(2-morpholinophenyl)morpholine (3.5 g) in the presence of phosphorus oxychloride for 35 hours at 80°-85° C. gave N,N-dimethyl-N'-(2-morpholinophenyl)piperidine-1-carboxamidine (m.p. 88°-90° C.) which was recrystallised from petroleum ether (b.p. 40°-60° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05373008 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-ae23cc6340b04cfaa51c5c497b824733 |
| Source note | uspto-grants-1994_12 |