Phosphorus oxychloride → HCID 15746466, compound

HRID 1492209Notes

Reaction equation

HRID 1492209 reaction equation
[CH3:1][N:2]([CH3:11])[C:3]([N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=O.[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:24]2CCOCC2)[CH2:14][CH2:13]1.P(Cl)(Cl)(Cl)=O>C1C=CC=CC=1>[CH3:1][N:2]([CH3:11])[C:3]([N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=[N:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[N:15]1[CH2:16][CH2:17][O:12][CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 992681-Piperidinecarboxamide, N,N-dimethyl-HCID 13479496HCID 13479496, compound

Product 1

HCID 15746466HCID 15746466, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Reaction of 1-dimethylcarbamoylpiperidine (3.7 g) in benzene (25 ml) with 4-(2-morpholinophenyl)morpholine (3.5 g) in the presence of phosphorus oxychloride for 35 hours at 80°-85° C. gave N,N-dimethyl-N'-(2-morpholinophenyl)piperidine-1-carboxamidine (m.p. 88°-90° C.) which was recrystallised from petroleum ether (b.p. 40°-60° C.)

Sources & evidence

ORD record
ord-ae23cc6340b04cfaa51c5c497b824733
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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