Sodium Hydroxide → HCID 15746488, compound

HRID 1492223Notes

Reaction equation

HRID 1492223 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[CH3:24])=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>O>[CH3:24][CH:20]1[CH2:21][CH2:22][CH2:23][N:19]1[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[NH:12][C:10]([NH2:9])=[S:11]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15746514HCID 15746514, compound

Product 1

HCID 15746488HCID 15746488, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1-benzoyl-3-[2-(2-methyl-1-pyrrolidinyl)phenyl]thiourea (9 g), sodium hydroxide (1 g, as pellets) and water (10 ml) was heated at 90°-95° C. for 48 hours to give 1-[2-(2-methyl-1-pyrrolidinyl)phenyl]thiourea (m.p. 145°-148° C.) which was purified by column chromatography on silica gel using a 1:1 mixture of ethylacetate and hexane as eluant.

Workup

  1. temperaturewas heated at 90°-95° C. for 48 hours

Sources & evidence

ORD record
ord-3e1c69cfb0a14f40b8a768d6a1807e28
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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