Methyl iodide → HCID 178503986, compound

HRID 1492228Notes

Reaction equation

HRID 1492228 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9]([NH2:11])=[S:10])=[C:6]([N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:5]=[CH:4][CH:3]=1.[CH3:18][I:19]>CO>[IH:19].[CH3:18][S:10][C:9](=[NH:11])[NH:8][C:7]1[C:2]([CH3:1])=[CH:3][CH:4]=[CH:5][C:6]=1[N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18952310HCID 18952310, compound

Product 1

HCID 178503986HCID 178503986, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-(6-methyl-2-piperidinophenyl)thiourea (7 g) and methyl iodide (4.38 g) in dry methanol (100 ml) was heated under reflux for 3 hours to give 2-methyl-1-(6-methyl-2-piperidinophenyl)-2-thiopseudourea hydroiodide as a pale yellow solid, (m.p. 204°-205° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours

Sources & evidence

ORD record
ord-d9452ef51cdf4608a531e2d8727958ca
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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