Propylenediamine → HCID 178430622, compound

HRID 1492229Notes

Reaction equation

HRID 1492229 reaction equation
I.CS[C:4](=[NH:18])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:19][CH:20]([NH2:23])[CH2:21]N>C(O)C>[CH3:19][CH:20]1[CH2:21][NH:18][C:4](=[N:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[NH:23]1

Participants

4

Reactant 2

HCID 6567PropylenediamineHCID 178503978HCID 178503978, compound

Product 1

HCID 178430622HCID 178430622, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (3.8 g prepared as described in Example 166), 2-methylethylenediamine (2.2 g) and ethanol (45 ml) was heated under reflux for 8 hours to give a solid which was recrystallised from ethyl acetate to give 4-[2-(4-methyl-2-imidazolidinylideneamino)phenyl]morpholine (m.p. 173°-174° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 8 hours
  3. customto give a solid which
  4. customwas recrystallised from ethyl acetate

Sources & evidence

ORD record
ord-dcc63166a80c4c7d823f9604ebd3b302
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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