Methyl iodide → HCID 18952225, compound

HRID 1492236Notes

Reaction equation

HRID 1492236 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:13][C:14]([NH:16][CH3:17])=[S:15])[CH2:3][CH2:2]1.[CH3:18][I:19]>CC(C)=O>[IH:19].[CH3:18][S:15][C:14](=[N:16][CH3:17])[NH:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 8625249HCID 8625249, compound

Product 1

HCID 18952225HCID 18952225, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1-(2-morpholinophenyl)-3-methylthiourea (5 g) and methyliodide (2.8 g) in acetone (30 ml) was heated at reflux for 4 hours to yield 2-methyl-1-(2-morpholinophenyl)-3-methyl-2-thiopseudourea hydroiodide (m.p. 163°-164° C.) which was recrystallised from a 1:3 mixture of methanol and ether.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours

Sources & evidence

ORD record
ord-187a899cb802444aa3eb12b96e9c43da
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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