Butyl Isothiocyanate → 1-(n-Butyl)-3-(2-morpholinophenyl)thiourea

HRID 1492240Notes

Reaction equation

HRID 1492240 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[CH2:14]([N:18]=[C:19]=[S:20])[CH2:15][CH2:16][CH3:17]>ClCCl>[CH2:14]([NH:18][C:19]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)=[S:20])[CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 11613Butyl IsothiocyanateHCID 7357562-Morpholinoaniline

Product 1

HCID 86252541-(n-Butyl)-3-(2-morpholinophenyl)thiourea

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-(2-aminophenyl)morpholine (5.8 g) in dichloromethane (60 ml) was treated with n-butyl isothiocyanate (5 g) and mixture stirred at room temperature for 4 days to yield 1-(n-butyl)-3-(2-morpholinophenyl)thiourea as a pale yellow solid (m.p. 105° C.).

Sources & evidence

ORD record
ord-1909c154fd1a48e2a96011edf8172013
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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