(2-(Methylthio)ethyl)amine → HCID 178503813, compound

HRID 1492244Notes

Reaction equation

HRID 1492244 reaction equation
I.CS[C:4](=[NH:18])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:19][S:20][CH2:21][CH2:22][NH2:23]>C(O)C>[CH3:19][S:20][CH2:21][CH2:22][NH:23][C:4]([NH2:18])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 87697(2-(Methylthio)ethyl)amineHCID 178503978HCID 178503978, compound

Product 1

HCID 178503813HCID 178503813, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (1.7 g) prepared as described in Example 166, 2-methylthioethylamine (1.8 g) and ethanol (25 ml) was heated at 90°-95° C. for 22 hours to give 1-(2-methylthioethyl)-2-(2-morpholinophenyl)guanidine (m.p. 115°-116° C.) which was recrystallised from hexane.

Workup

  1. customprepared
  2. temperaturewas heated at 90°-95° C. for 22 hours

Sources & evidence

ORD record
ord-170d2265effa46d3a758d8be2564e12b
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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