2-Methoxyethylamine → HCID 178495973, compound

HRID 1492245Notes

Reaction equation

HRID 1492245 reaction equation
I.CS[C:4](=[NH:18])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:19][O:20][CH2:21][CH2:22][NH2:23]>C(O)C>[CH3:19][O:20][CH2:21][CH2:22][NH:23][C:4]([NH2:18])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 178503978HCID 178503978, compound

Product 1

HCID 178495973HCID 178495973, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (7.6 g), 2-methoxyethylamine (2 ml) and ethanol (45 ml) was stirred at ambient temperature for 14 days to give 1-(2-methoxyethyl)-2-(2-morpholinophenyl)guanidine (m.p. 125°-128° C.) which was recrystallised from 1,2-dimethoxyethane and converted into its fumarate salt (m.p. 136°-138° C.) which was recrystallised from a 1:2 mixture of methanol and ether.

Sources & evidence

ORD record
ord-4e66942941fa44e985dfb68ddc8a2627
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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