Ethanol → HCID 178484907, compound

HRID 1492246Notes

Reaction equation

HRID 1492246 reaction equation
I.CS[C:4](=[N:18][CH3:19])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:20][O:21][CH2:22][CH2:23][NH2:24].C(O)C.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>CO>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[CH3:19][NH:18][C:4]([NH:24][CH2:23][CH2:22][O:21][CH3:20])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

6

Reactant 4

HCID 702EthanolHCID 80182-MethoxyethylamineHCID 444972Fumaric AcidHCID 18952225HCID 18952225, compound

Product 1

HCID 178484907HCID 178484907, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-3-methyl-2-thiopseudourea hydroiodide (3.9 g prepared as described in Example 210), 2-methoxyethylamine (0.82 g) and ethanol (25 ml) was stored at ambient temperature for three months to yield an oil which was dissolved in methanol and treated with fumaric acid to give 1-methyl-2-(2-morpholinophenyl)-3-(2-methoxyethyl)guanidine monofumarate (m.p. 158°-160° C.) which was recrystallised from a 1:2 mixture of methanol and ether.

Workup

  1. waitwas stored at ambient temperature for three months
  2. customto yield an oil which

Sources & evidence

ORD record
ord-187e2d20982b46ed8003bdd78afef3c7
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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