Butyl Isothiocyanate → 1-(n-Butyl)-3-(5-chloro-2-morpholinophenyl)thiourea

HRID 1492250Notes

Reaction equation

HRID 1492250 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[C:6]([CH:8]=1)[NH2:7].[CH2:15]([N:19]=[C:20]=[S:21])[CH2:16][CH2:17][CH3:18]>C(O)C>[CH2:15]([NH:19][C:20]([NH:7][C:6]1[CH:8]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)=[S:21])[CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 11613Butyl IsothiocyanateHCID 8461895-Chloro-2-(morpholin-4-yl)aniline

Product 1

HCID 189522771-(n-Butyl)-3-(5-chloro-2-morpholinophenyl)thiourea

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 5-chloro-2-morpholinoaniline (2.8 g) (2.8 g) with n-butyl isothiocyanate (1.5 g) in ethanol (20 ml) at room temperature for 60 days yielded 1-(n-butyl)-3-(5-chloro-2-morpholinophenyl)thiourea (m.p. 150°-152° C.).

Sources & evidence

ORD record
ord-7941c82753304f69b45c0214d800a568
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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