Methylamine → HCID 178484924, compound

HRID 1492252Notes

Reaction equation

HRID 1492252 reaction equation
I.CS[C:4](=[N:19][CH2:20]CCC)[NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[CH3:24][NH2:25]>>[CH3:24][NH:25][C:4]([NH:19][CH3:20])=[N:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 189522972-Methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide

Product 1

HCID 178484924HCID 178484924, compound

Procedure

A mixture of 2-methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide (3.4 g) and a 33% ethanolic solution of methylamine (10 ml) were stored at ambient temperature in a sealed container for 8 months to yield 1,3-dimethyl-2-(5-chloro-2-morpholinophenyl)guanidine (m.p. 145°-146° C.) which was recrystallised from hexane. In this reaction the butylamino and the methylthio group of the starting material are replaced by a methylamino group.

Sources & evidence

ORD record
ord-1ce9eaf7e87c4b59b54ff885d0b84d91
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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