Methyl iodide → HCID 18952112, compound

HRID 1492254Notes

Reaction equation

HRID 1492254 reaction equation
[CH3:1][NH:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)=[S:4].[CH3:17][I:18]>CC(C)=O>[IH:18].[CH3:17][S:4][C:3](=[N:2][CH3:1])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 15746499HCID 15746499, compound

Product 1

HCID 18952112HCID 18952112, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1-methyl-3-[2-(1-pyrrolidinyl)phenyl]thiourea (18.5 g) and methyl iodide (12.3 g) and acetone (100 ml) was heated under reflux for 2.5 hours to give 2-methyl-1-[2-(1-pyrrolidinyl)phenyl]-3-methyl-2-thiopseudourea hydroiodide (m.p. 161°-162° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours

Sources & evidence

ORD record
ord-74e1f5809c9c41aa84bbe5b8693e3fa9
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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