Methylamine → HCID 178484912, compound

HRID 1492258Notes

Reaction equation

HRID 1492258 reaction equation
I.CS[C:4](=[N:19][CH3:20])[NH:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[CH3:21][NH2:22]>C(O)C>[CH3:20][NH:19][C:4]([NH:22][CH3:21])=[N:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 18952165HCID 18952165, compound

Product 1

HCID 178484912HCID 178484912, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-methyl-1-(5-methyl-2-morpholinophenyl)-3-methyl-2-thiopseudourea hydroiodide (6 g) and 33% methylamine in absolute ethanol solution (250 ml) was kept at room temperature for 21 days to yield 1,3-dimethyl-2-(5-methyl-2-morpholinophenyl)guanidine as an oil which was dissolved in methanol (60 ml) and treated with fumaric acid (1.7 g) to give 1,3-dimethyl-2-(5-methyl-2-morpholinophenyl)guanidine fumarate (1.2 g) as a colourless solid which was recrystallised from a 1:1 mixture of methanol and ether (m.p. 201°-202° C.).

Sources & evidence

ORD record
ord-4bd9123c47f34b2191b3433add5c1b61
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

Loading…