Dimethylamine → 1,1-Dimethyl-2-(2-morpholinophenyl)guanidine

HRID 1492266Notes

Reaction equation

HRID 1492266 reaction equation
CS[C:3](=[NH:17])[NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.[CH3:18][NH:19][CH3:20]>C(N(CC)CC)C>[CH3:18][N:19]([CH3:20])[C:3]([NH2:17])=[N:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 178503977HCID 178503977, compound

Product 1

HCID 98854071,1-Dimethyl-2-(2-morpholinophenyl)guanidine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroidide (3.8 g), a 33% ethanolic solution of dimethylamine (5 ml) and triethylamine (25 ml) was heated at 80° C. for 8 hours. Triethylamine was removed by evaporation under reduced pressure and the residue treated with a mixture of ice and water to give 1,1-dimethyl-2-(2-morpholinophenyl)guanidine (m.p. 141°-143° C.) which was recrystallised from hexane.

Workup

  1. customTriethylamine was removed by evaporation under reduced pressure
  2. additionthe residue treated with a mixture of ice and water

Sources & evidence

ORD record
ord-564e910fd6d94e02b14e69de64fc724d
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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