Dimethylamine → HCID 18952216, compound

HRID 1492269Notes

Reaction equation

HRID 1492269 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][C:8]=2[NH:17][C:18]([NH2:20])=S)[CH2:3][CH2:2]1.[OH-].[K+].[CH3:23][NH:24][CH3:25].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>C(O)C>[CH3:23][N:24]([CH3:25])[C:18]([NH2:20])=[N:17][C:8]1[CH:9]=[C:10]([C:13]([F:16])([F:15])[F:14])[CH:11]=[CH:12][C:7]=1[N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

Participants

6

Reactant 4

HCID 674DimethylamineHCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 18952324HCID 18952324, compound

Product 1

HCID 18952216HCID 18952216, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(2-morpholino-5-trifluoromethylphenyl)thiourea (6.1 g), potassium hydroxide (2.2 g), a 33% ethanolic solution of dimethylamine (5.6 ml), lead acetate trihydrate (7.5 g) and ethanol (40 ml) was heated at 90°-95° C. for 2 hours to yield 1,1-dimethyl-2-(2-morpholino-5-trifluoromethylphenyl)guanidine (m.p. 132°-135° C.) which was recrystallised from ethylacetate and converted into its fumarate salt (m.p. 228°-230° C.) which was recrystallised from a 1:2 mixture of methanol and ether.

Sources & evidence

ORD record
ord-c7de247ade5740f58e4e3f3de2b3aeb3
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

Loading…