Dimethylamine → HCID 18952216, compound

Participants

Reaction Steps

A mixture of 1-(2-morpholino-5-trifluoromethylphenyl)thiourea (6.1 g), potassium hydroxide (2.2 g), a 33% ethanolic solution of dimethylamine (5.6 ml), lead acetate trihydrate (7.5 g) and ethanol (40 ml) was heated at 90°-95° C. for 2 hours to yield 1,1-dimethyl-2-(2-morpholino-5-trifluoromethylphenyl)guanidine (m.p. 132°-135° C.) which was recrystallised from ethylacetate and converted into its fumarate salt (m.p. 228°-230° C.) which was recrystallised from a 1:2 mixture of methanol and ether.

Provenance & Evidence