反应详情

N-(2-morpholinophenyl)cyanamide (2 g) was heated under reflux with a 33% solution of dimethylamine in ethanol (15 ml) for 4 hours. The mixture was then cooled and the solvent removed by evaporation to give a residue which was suspended in 20% aqueous sodium hydroxide solution. The suspension was extracted with dichloromethane (3×25 ml) and the extracts were washed with water, and then brine, dried and evaporated to give 1,1-dimethyl-2-(2-morpholinophenyl) guanidine (m.p. 142°-143° C.) which was recrystallised from hexane.

1. temperatureThe mixture was then cooled
2. customthe solvent removed by evaporation
3. customto give a residue which
4. extractionThe suspension was extracted with dichloromethane (3×25 ml)
5. washthe extracts were washed with water
6. dry with materialbrine, dried
7. customevaporated