Dimethylamine → 1,1-Dimethyl-2-(2-morpholinophenyl)guanidine

Participants

Reaction Steps

N-(2-morpholinophenyl)cyanamide (2 g) was heated under reflux with a 33% solution of dimethylamine in ethanol (15 ml) for 4 hours. The mixture was then cooled and the solvent removed by evaporation to give a residue which was suspended in 20% aqueous sodium hydroxide solution. The suspension was extracted with dichloromethane (3×25 ml) and the extracts were washed with water, and then brine, dried and evaporated to give 1,1-dimethyl-2-(2-morpholinophenyl) guanidine (m.p. 142°-143° C.) which was recrystallised from hexane.

Provenance & Evidence