Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 4418042 | HCID 4418042 | 86% |
Reaction Steps
The pyridine derivative of the present invention is represented by the general formula A or B. For example, 50 g of 2-chloro-5-nitropyridine and 150 ml of diethylamine were placed in a sealed tube and heated at 120° C. for 7 hr. Pure water was added to the precipitated crystal, and the crystal was collected by filtration and recrystallized from 300 ml of methanol to give 53 g of 2-diethylamino-5-nitropyridine (yield: 86%, melting point: 75° to 76° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05374601 |
|---|
| Source dataset | uspto-grants-1994_12 |
|---|
| ORD ID | ord-c19cd45deb864689ac4a67f0275952f3 |
|---|
| Source note | uspto-grants-1994_12 |
|---|
