Pyridine → HCID 4418042, compound

HRID 1492373Notes

Reaction equation

HRID 1492373 reaction equation
[N:1]1[CH:6]=[CH:5]C=[CH:3][CH:2]=1.Cl[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][N:9]=1.C(NCC)C>O>[CH2:2]([N:1]([CH2:6][CH3:5])[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][N:9]=1)[CH3:3]

Participants

5

Reactant 3

HCID 1049PyridineHCID 8021DiethylamineHCID 783082-Chloro-5-nitropyridine

Product 1

HCID 4418042HCID 4418042, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

The pyridine derivative of the present invention is represented by the general formula A or B. For example, 50 g of 2-chloro-5-nitropyridine and 150 ml of diethylamine were placed in a sealed tube and heated at 120° C. for 7 hr. Pure water was added to the precipitated crystal, and the crystal was collected by filtration and recrystallized from 300 ml of methanol to give 53 g of 2-diethylamino-5-nitropyridine (yield: 86%, melting point: 75° to 76° C.).

Workup

  1. filtrationthe crystal was collected by filtration
  2. customrecrystallized from 300 ml of methanol

Sources & evidence

ORD record
ord-c19cd45deb864689ac4a67f0275952f3
Source dataset
uspto-grants-1994_12
Patent number
US05374601

Reaction notes

Loading…