Hydroxyamine hydrochloride → HCID 18950314, compound

HRID 1492381Notes

Reaction equation

HRID 1492381 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:19])[C:9](=[CH:15]OCC)[C:10]([CH:12]2[CH2:14][CH2:13]2)=[O:11])=[C:4]([S:20][CH3:21])[C:3]=1[CH2:22][S:23][CH3:24].Cl.[NH2:26]O.C([O-])(=O)C.[Na+]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:9]2[CH:15]=[N:26][O:11][C:10]=2[CH:12]2[CH2:14][CH2:13]2)=[O:19])=[C:4]([S:20][CH3:21])[C:3]=1[CH2:22][S:23][CH3:24]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 54397850HCID 54397850, compound

Product 1

HCID 18950314HCID 18950314, compoundYield 21.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-[4-chloro-3-(methylsulphenylmethyl)-2-(methylsulphenyl)phenyl]-2-ethoxymethylene-3-cyclopropylpropan-1,3-dione (2.3 g), hydroxylamine hydrochloride (0.52 g) and sodium acetate (0.46 g) in ethanol was stirred at room temperature overnight. The resulting mixture was filtered and the solid collected, washed with water and air dried to yield 4-[4-chloro-2-(methylsulphenyl)-3-(methylsulphenylmethyl)benzoyl]-5-cyclopropylisoxazole (Compound 3, 0.46 g) as a yellow solid, m.p. 79.9°-80.5° C.

Workup

  1. filtrationThe resulting mixture was filtered
  2. customthe solid collected
  3. washwashed with water and air
  4. customdried

Sources & evidence

ORD record
ord-01dca6888c8046d789d189addf76d504
Source dataset
uspto-grants-1994_12
Patent number
US05374606

Reaction notes

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