HCID 131718799, compound → HCID 131718798, compound

HRID 1492397Notes

Reaction equation

HRID 1492397 reaction equation
C[O:2][C:3](=[O:16])[C:4]([NH2:15])([CH3:14])[CH2:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)=[O:7]>CO>[N:8]1([C:6]([CH2:5][C:4]([NH2:15])([CH3:14])[C:3]([OH:16])=[O:2])=[O:7])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

3

Reactant 1

HCID 131718799HCID 131718799, compound

Product 1

HCID 131718798HCID 131718798, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Conversion to the acid. Morpholine carbonyl-2-aminoisobutyric methyl ester (5.65 mmol) is dissolved in 60 ml of methanol containing 6 ml (1 N) sodium hydroxide and is stirred under argon overnight. The reaction is then concentrated, diluted with ethyl acetate and extracted with water (50 ml) containing 7 ml 1 N sodium hydroxide. The water is neutralized and extracted with ethyl acetate, and is then dried (Na2SO4) and concentrated to give a white solid, m.p. 162°-166° C.

Workup

  1. concentrationThe reaction is then concentrated
  2. additiondiluted with ethyl acetate
  3. extractionextracted with water (50 ml)
  4. additioncontaining 7 ml 1 N sodium hydroxide
  5. extractionextracted with ethyl acetate
  6. dry with materialis then dried (Na2SO4)
  7. concentrationconcentrated
  8. customto give a white solid, m.p. 162°-166° C.

Sources & evidence

ORD record
ord-575cbb2e22294515b49774ac3c0d0176
Source dataset
uspto-grants-1994_12
Patent number
US05374623

Reaction notes

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