HCID 131718799, compound → HCID 131718798, compound

Participants

Reaction Steps

Conversion to the acid. Morpholine carbonyl-2-aminoisobutyric methyl ester (5.65 mmol) is dissolved in 60 ml of methanol containing 6 ml (1 N) sodium hydroxide and is stirred under argon overnight. The reaction is then concentrated, diluted with ethyl acetate and extracted with water (50 ml) containing 7 ml 1 N sodium hydroxide. The water is neutralized and extracted with ethyl acetate, and is then dried (Na2SO4) and concentrated to give a white solid, m.p. 162°-166° C.

Provenance & Evidence