HCID 18950654, compound → HCID 178519224, compound

HRID 1492420Notes

Reaction equation

HRID 1492420 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[NH:8][O:9][C:10](=[O:12])[CH:11]=2)[CH:2]=1.[N:13]([O-])=[O:14].[Na+]>O.C(O)(=O)C>[N:13](=[C:11]1[C:10](=[O:12])[O:9][N:8]=[C:7]1[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[OH:14]

Participants

5

Reactant 2

HCID 18950654HCID 18950654, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 178519224HCID 178519224, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

A suspension of 57 g of 3-(pyrid-3-yl)isoxazol-5-one in 50 ml of water and 350 ml of glacial acetic acid is treated dropwise at 15° C. with a solution of 27 g of sodium nitrite in 60 ml of water. After 4 hours, the precipitate is filtered off with suction, washed with water and dried.

Workup

  1. filtrationthe precipitate is filtered off with suction
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-d1667e8a2bf548ef9e32194f242df821
Source dataset
uspto-grants-1994_12
Patent number
US05374640

Reaction notes

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