(4-Methylphenyl)hydrazine → HCID 2728171, compound

HRID 1492478Notes

Reaction equation

HRID 1492478 reaction equation
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([NH:7][NH2:8])=[CH:3][CH:2]=1.[C:10]([O:15][CH2:16][CH3:17])(=[O:14])[C:11]([CH3:13])=O>C(Cl)Cl>[CH3:9][C:1]1[CH:6]=[CH:5][C:4]([NH:7][N:8]=[C:11]([CH3:13])[C:10]([O:15][CH2:16][CH3:17])=[O:14])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 10875(4-Methylphenyl)hydrazineHCID 12041Ethyl pyruvate

Product 1

HCID 2728171HCID 2728171, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

para-Tolylhydrazine (1.2024 g, 9.84 mmol, 1.0 eq.) was combined with ethyl pyruvate (1.08 ml, 9.84 mmol, 1.0 eq.) and 3A sieves (3.6 g, 300% by weight) in methylene chloride (9.8 ml, 1M) at room temperature. After 30 minutes, the reaction was filtered through anhydrous magnesium sulfate and concentrated to give the title A compound (2.095 g) which was used in the next step without purification or characterization.

Workup

  1. filtrationthe reaction was filtered through anhydrous magnesium sulfate
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-eb88c64f18664d64b0e1aff25adef8aa
Source dataset
uspto-grants-1994_12
Patent number
US05374615

Reaction notes

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