Thionyl Chloride → HCID 18951158, compound

HRID 1492497Notes

Reaction equation

HRID 1492497 reaction equation
[NH:1]([CH2:8][C:9]([O:11][C:12]1([CH3:17])[CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][C:19]1[CH:20]=[C:21]([NH:25][C:26](=[O:32])[NH:27][CH2:28][C:29](O)=[O:30])[CH:22]=[CH:23][CH:24]=1.S(Cl)(Cl)=O>>[CH3:18][C:19]1[CH:20]=[C:21]([NH:25][C:26](=[O:32])[NH:27][CH2:28][C:29]([N:1]([CH2:8][C:9]([O:11][C:12]2([CH3:17])[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:10])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:30])[CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 149969602-{[(3-Methylphenyl)carbamoyl]amino}acetic acidHCID 18951128HCID 18951128, compound

Product 1

HCID 18951158HCID 18951158, compoundYield 7.2%

Procedure

Following a procedure analogous to that described in Example 1, but using 4.8 g of 1-methylcyclopentyl 2-anilinoacetate, 4.1 g of 2-[3-(3-methylphenyl)ureido]acetic acid and 1.4 cm3 of thionyl chloride as starting materials, 0.6 g of 1-methylcyclopentyl 2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetate melting at 160° C. is obtained after recrystallization from an acetonitrile/diisopropyl ether mixture (40/60 by volume).

Sources & evidence

ORD record
ord-c95d251d70414debb624c5d444e41fcf
Source dataset
uspto-grants-1994_12
Patent number
US05374656

Reaction notes

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