Ethanol → HCID 18950735, compound

HRID 1492520Notes

Reaction equation

HRID 1492520 reaction equation
[C:1]1([CH3:32])[CH:6]=[CH:5][C:4]([S:7]([NH:10][CH:11]([C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)[CH2:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([O:21]CC)=[O:20])=[CH:15][CH:14]=2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+].[CH2:35](O)[CH3:36]>O1CCCC1>[CH2:35]([CH:18]([O:17][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][CH:11]([NH:10][S:7]([C:4]2[CH:5]=[CH:6][C:1]([CH3:32])=[CH:2][CH:3]=2)(=[O:9])=[O:8])[C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:25][CH:24]=1)[C:19]([OH:21])=[O:20])[CH3:36]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 15232178HCID 15232178, compound

Product 1

HCID 18950735HCID 18950735, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 4-[2-(4-toluene sulfonamido)-2-(3-pyridyl)ethyl]phenoxyacetate (90 mg) was dissolved in 2 ml of ethanol and 2 ml of tetrahydrofuran, followed by addition of 0.30 ml of aqueous 2N sodium hydroxide solution, and stirred at room temperature for one hour. The solvent was concentrated under reduced pressure, and neutralized with 2N hydrogen chloride. Then, the crystalline deposited was taken out by filtration, to yield 80 mg of ethyl 4-[2-(4-toluene sulfonamido)-2-(3-pyridyl)- ethyl]phenoxyacetic acid.

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. filtrationThen, the crystalline deposited was taken out by filtration

Sources & evidence

ORD record
ord-5a3e298f0c014d1e9cf291a309792653
Source dataset
uspto-grants-1994_12
Patent number
US05374641

Reaction notes

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