Ammonium formate → HCID 18950680, compound

HRID 1492534Notes

Reaction equation

HRID 1492534 reaction equation
O=[C:2]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:5]=1.[CH:21]([O-:23])=O.[NH4+:24]>O>[CH:21]([NH:24][CH:2]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:5]=1)=[O:23]

Participants

4

Reactant 2

HCID 2723923Ammonium formateHCID 18950748HCID 18950748, compound

Product 1

HCID 18950680HCID 18950680, compoundYield 2.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 13 g of methyl 4-[2-oxo-2-(3-pyridyl)ethyl]phenylacetate was added 8.0 g of ammonium formate, and reacted at 150° C. for four hours. After cooling, water was added, followed by extraction with chloroform. The chloroform phase obtained was washed in saturated aqueous sodium chloride solution and dried over magnesium sulfate, followed by distillation of the solvent, to produce 0.38 g of methyl 4-[2-formamido-2-(3-pyridyl)ethyl]phenylacetate.

Workup

  1. customreacted at 150° C. for four hours
  2. temperatureAfter cooling
  3. extractionfollowed by extraction with chloroform
  4. customThe chloroform phase obtained
  5. washwas washed in saturated aqueous sodium chloride solution
  6. dry with materialdried over magnesium sulfate
  7. distillationfollowed by distillation of the solvent

Sources & evidence

ORD record
ord-e8dfc4cfb4cc4e79a1f11ffe300a62c4
Source dataset
uspto-grants-1994_12
Patent number
US05374641

Reaction notes

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