HCID 18950679, compound → HCID 18950677, compound

HRID 1492543Notes

Reaction equation

HRID 1492543 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH2:28][C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH2:16][NH:17][S:18]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH2:28][C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH2:16][NH:17][S:18]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])=[CH:11][CH:10]=1

Participants

5

Reactant 2

HCID 18950679HCID 18950679, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18950677HCID 18950677, compoundYield 59%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The N-[2-(4-benzyloxyphenyl)-3-(3-pyridyl)propyl]-4-chlorobenzenesulfonamide (170 mg) was dissolved in 10 ml of ethanol, followed by addition of 0.2 g of 10% palladium carbon, and stirred for catalytic reduction via hydrogen at 55° C. overnight, to obtain 82 mg of N-[2-(4-hydroxyphenyl)-3-(3-pyridyl)propyl]-4-chlorobenzenesulfonamide.

Sources & evidence

ORD record
ord-c503ba70d510426ca868be241eaf36e5
Source dataset
uspto-grants-1994_12
Patent number
US05374641

Reaction notes

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