tert-Butyldimethylsilyl chloride → HCID 19385687, compound

HRID 1492573Notes

Reaction equation

HRID 1492573 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[OH:12])[C:5]([O:7][CH3:8])=[O:6].[C:13]([Si:17]([CH3:20])([CH3:19])Cl)([CH3:16])([CH3:15])[CH3:14]>C(Cl)Cl.CN(C)C1C=CN=CC=1>[Si:17]([O:12][C:11]1[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=1[Cl:1])([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:20])[CH3:19]

Participants

5

Reactant 2

HCID 28928tert-Butyldimethylsilyl chlorideHCID 77580Methyl 3-chloro-4-hydroxybenzoate

Product 1

HCID 19385687HCID 19385687, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 5.00 g (26.8 mmol) of methyl 3-chloro-4-hydroxybenzoate dissolved in 40 mL of CH2Cl2 was added 6.55 g (53.6 mmol) of 4-dimethylaminopyridine, 4.85 g (32.2 mmol) of tert-butyldimethylchlorosilane and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was filtered, diluted with ethyl acetate, washed with 0.1 N HCl, saturated NaHCO3, and brine. The product layer was then dried (MgSO4), filtered and evaporated in vacuo to afford 8.05 g (100%) of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. additiondiluted with ethyl acetate
  3. washwashed with 0.1 N HCl, saturated NaHCO3, and brine
  4. dry with materialThe product layer was then dried (MgSO4)
  5. filtrationfiltered
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-80569c3f0fce43d5b076696cb3c26d74
Source dataset
uspto-grants-1994_12
Patent number
US05374638

Reaction notes

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