HRID1492615

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81503

Bromomethylcyclopropane

C4H7Br

结构：CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)OC)c2ccccc2)cc1

HCID10251994

未命名化合物

HCID178418261

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)OC)c2ccccc2)cc1

HCID10412994

未命名化合物

PROCEDURE

实验过程

Using the general procedure for the alkylation of secondary amines with LiN(TMS)2 described in Step A of Example 29, 3-[4-(N-(1-carbomethoxy -1-phenylmethyl)amino)phenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]-pyridine (Step A, Example 28) was alkylated with cyclopropylmethyl bromide. Standard workup and purification by flash chromatography afforded the title compound.

WORKUP

后处理

customStandard workup and purification by flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-80e117ef98e9454589ef4079f7796040
来源数据集: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05374638
来源说明: uspto-grants-1994_12

反应 SMILES

[Li]N([Si](C)(C)C)[Si](C)(C)C.[C:11]([CH:15]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][N:30]2[C:34]3=[N:35][C:36]([CH3:40])=[CH:37][C:38]([CH3:39])=[C:33]3[N:32]=[C:31]2[CH2:41][CH3:42])=[CH:25][CH:24]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([O:13][CH3:14])=[O:12].[CH:43]1([CH2:46]Br)[CH2:45][CH2:44]1>>[C:11]([CH:15]([N:22]([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][N:30]2[C:34]3=[N:35][C:36]([CH3:40])=[CH:37][C:38]([CH3:39])=[C:33]3[N:32]=[C:31]2[CH2:41][CH3:42])=[CH:25][CH:24]=1)[CH2:46][CH:43]1[CH2:45][CH2:44]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)([O:13][CH3:14])=[O:12]