反应详情

To a solution of 1.260 g (4.80 mmol) of methyl α-bromo-(3-chlorophenyl)acetate and 0.600 g (4.00 mmol) of 3,5-dimethyl-4-hydroxybenzaldehyde in 16 mL acetone was added 1.10 g (8.00 mmol) of potassium carbonate and the resulting mixture was stirred and heated at reflux for 3.5 hours. The reaction mixture was cooled to room temperature, filtered and concentrated in vacuo. The residue was purified on a silica gel flash chromatography column eluted with 30% EtOAc-hexane. The purified fractions were combined, evaporated and dried in vacuo to afford 1.260 g (95%) of the title compound.

1. temperatureheated
2. temperatureat reflux for 3.5 hours
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe residue was purified on a silica gel flash chromatography column
6. washeluted with 30% EtOAc-hexane
7. customevaporated
8. customdried in vacuo