HRID1492649

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID14798

Sodium Hydroxide

HNaO

结构：CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(CCc1ccccc1)C(=O)OCC

HCID54160410

未命名化合物

PRODUCTS

生成物

结构：CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(CCc1ccccc1)C(=O)O

HCID18950595

未命名化合物

收率 79%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

To a magnetically stirred solution of 0.138 g (0.25 mmol) of the product of Step A in 1.0 mL ethanol was added 0.5 mL of a 5.0N solution of sodium hydroxide and the reaction was stirred at room temperature overnight. The reaction mixture was adjusted to pH=6 with 1.0N hydrochloric acid and then concentrated in vacuo. The residue was then purified on a silica gel flash chromatography column eluted with CHCl3 --MeOH--NH4OH (80:15:1). Evaporation of the purified fractions and drying in vacuo afforded 0.103 g (79%) of the title compound.

WORKUP

后处理

concentrationconcentrated in vacuo
customThe residue was then purified on a silica gel flash chromatography column
washeluted with CHCl3 --MeOH--NH4OH (80:15:1)
customEvaporation of the purified fractions
customdrying in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a803a993869840f7a8197aaaa05ef209
来源数据集: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05374638
来源说明: uspto-grants-1994_12

反应 SMILES

[C:1]([CH:6]([CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[O:7][C:8]1[C:13]([CH2:14][CH2:15][CH3:16])=[CH:12][C:11]([CH2:17][N:18]2[C:22]3=[N:23][C:24]([CH3:28])=[CH:25][C:26]([CH3:27])=[C:21]3[N:20]=[C:19]2[CH2:29][CH3:30])=[CH:10][C:9]=1[CH2:31][CH2:32][CH3:33])([O:3]CC)=[O:2].[OH-].[Na+].Cl>C(O)C>[C:1]([CH:6]([CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[O:7][C:8]1[C:13]([CH2:14][CH2:15][CH3:16])=[CH:12][C:11]([CH2:17][N:18]2[C:22]3=[N:23][C:24]([CH3:28])=[CH:25][C:26]([CH3:27])=[C:21]3[N:20]=[C:19]2[CH2:29][CH3:30])=[CH:10][C:9]=1[CH2:31][CH2:32][CH3:33])([OH:3])=[O:2]