反应详情

Ethyl 2-amino-3-oxobutanoate hydrochloride (5 g) was added portionwise to a solution of ethyl ethaneimidate (34.0 g) and triethylamine (42 ml) in ethanol (500 ml), and the resulting yellow solution was stirred overnight. Solvent was removed in vacuo and the residue partitioned between water (200 ml) and ether (200 ml). The organic layer was separated and the aqueous phase further extracted with ether (2×200 ml). The dried organic extracts were evaporated in vacuo and the residue washed with cold ether and filtered to give the title compound as a white solid (1.1 g). m.p. 165-166° C.

1. customSolvent was removed in vacuo
2. customthe residue partitioned between water (200 ml) and ether (200 ml)
3. customThe organic layer was separated
4. extractionthe aqueous phase further extracted with ether (2×200 ml)
5. customThe dried organic extracts were evaporated in vacuo
6. washthe residue washed with cold ether
7. filtrationfiltered