HRID1492817

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2724682

2-Propanamine, N-(1-methylethyl)-, lithium salt

C6H14LiN

HCID14068168

未命名化合物

反应SMILES：C=CCOC(=O)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CI

HCID57112975

未命名化合物

PRODUCTS

产物

反应SMILES：C=CCOC(=O)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CC1CNC1=O

HCID56992111

未命名化合物

收率 24.5%

PROCEDURE

实验过程

The same procedure as in Reference Example 22-1 was carried out by using N-tert-butyldimethylsilyl-2-oxoazetidine (650 mg, 3.5 mmol), lithium diisopropylamide (2.1M tetrahydrofuran solution, 3.34 ml, 7.0 mmol), and (2S,4S)-N-allyloxycarbonyl-2-iodomethyl-4-tritylthiopyrrolidine (1 g, 1.75 mmol) to obtain (2R,4S)-N-allyloxycarbonyl-2-(2-oxoazetidin-3-ylmethyl)-4-tritylthiopyrrolidine (220 mg, yield: 24%).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-e17b1605f73a4b06ba6fc7eaf5e269f3
来源数据集: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05374720
来源说明: uspto-grants-1994_12

反应SMILES

[Si]([N:8]1[CH2:11][CH2:10][C:9]1=[O:12])(C(C)(C)C)(C)C.C([N-]C(C)C)(C)C.[Li+].[CH2:21]([O:24][C:25]([N:27]1[CH2:31][C@@H:30]([S:32][C:33]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:29][C@H:28]1[CH2:52]I)=[O:26])[CH:22]=[CH2:23]>>[CH2:21]([O:24][C:25]([N:27]1[CH2:31][C@@H:30]([S:32][C:33]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)([C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:29][C@H:28]1[CH2:52][CH:10]1[CH2:11][NH:8][C:9]1=[O:12])=[O:26])[CH:22]=[CH2:23]