Hydrazine hydrate (1:1) → HCID 15230137, compound

HRID 1492887Notes

Reaction equation

HRID 1492887 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[S:7][CH2:8][CH2:9][N:10]1C(=O)C2=CC=CC=C2C1=O.O.NN>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[S:7][CH2:8][CH2:9][NH2:10]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2553006HCID 2553006, compound

Product 1

HCID 15230137HCID 15230137, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-[2-(2-pyrimidinylthio)ethyl]phthalimide (17.1 g), hydrazine hydrate (21 g) and ethanol (200 ml) was stirred for one hour under reflux. The crystals separated was filtered off, and the filtrate was concentrated under reduced pressure to obtain 2-(2-pyrimidinylthio)ethylamine (6.6 g 71%) as an oil.

Workup

  1. temperatureunder reflux
  2. customThe crystals separated
  3. filtrationwas filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-88684cb6b4624f359f635883f6a20e1c
Source dataset
uspto-grants-1994_12
Patent number
US05376647

Reaction notes

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