2-Bromoethylamine hydrobromide → 5-Chloro-3-hydroxy-2-(2-bromoethyl)-1-oxoisoindolin

HRID 1492923Notes

Reaction equation

HRID 1492923 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([C:10]([OH:12])=O)[CH:3]=1.Br.[Br:14][CH2:15][CH2:16][NH2:17]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:8][CH:9]=1)[C:6](=[O:7])[N:17]([CH2:16][CH2:15][Br:14])[CH:10]2[OH:12]

Participants

3

Reactant 2

HCID 27742172-Bromoethylamine hydrobromideHCID 71762095-Chloro-2-formylbenzoic acid

Product 1

HCID 189498935-Chloro-3-hydroxy-2-(2-bromoethyl)-1-oxoisoindolinYield 27.8%

Procedure

The compound was prepared as described in example 1A, starting from 2.5 g (0.013 mole) of 4-chloro-2-carboxybenzaldehyde (I1 farmaco, Ed. Sci 31, 691, 1976) and 2.76 g (0.013 mole) of 2-bromoethylamine hydrobromide. 1.05 g of the title product were obtained; mp=164°-168 ° C. (n-hexane).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-fa9467be68e34ecfb893ccc54f11c2ad
Source dataset
uspto-grants-1994_12
Patent number
US05376673

Reaction notes

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