HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoethylamine hydrobromide → 5-Chloro-3-hydroxy-2-(2-bromoethyl)-1-oxoisoindolin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoethylamine hydrobromide | HCID 2774217 | — |
| Reactant | 5-Chloro-2-formylbenzoic acid | HCID 7176209 | — |
| Product | 5-Chloro-3-hydroxy-2-(2-bromoethyl)-1-oxoisoindolin | HCID 18949893 | 27.8% |
Reaction Steps
The compound was prepared as described in example 1A, starting from 2.5 g (0.013 mole) of 4-chloro-2-carboxybenzaldehyde (I1 farmaco, Ed. Sci 31, 691, 1976) and 2.76 g (0.013 mole) of 2-bromoethylamine hydrobromide. 1.05 g of the title product were obtained; mp=164°-168 ° C. (n-hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05376673 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-fa9467be68e34ecfb893ccc54f11c2ad |
| Source note | uspto-grants-1994_12 |