HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → 4-Fluoro-7-methoxy-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluoro-7-hydroxy-2,3-dihydro-1H-inden-1-one | HCID 15268488 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-Fluoro-7-methoxy-2,3-dihydro-1H-inden-1-one | HCID 14645028 | — |
Reaction Steps
In a nitrogen atmosphere, to 300 g powdered potassium carbonate in 1.5 1 of acetone is added 121 g II under stirring, followed by 83 ml of dimethyl sulphate. After heating to reflux for 2 hrs, the solvent is distilled off, water is added and the mixture refluxed for a further hour. Extraction with methylene chloride and evaporation gives 125 g of crude III, which is purified by crystallization from EtOAc, m.p. 118°-120°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05376687 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-648bc41352814c19b6de55e09197bcdd |
| Source note | uspto-grants-1994_12 |