反应详情

In a nitrogen atmosphere, to 300 g powdered potassium carbonate in 1.5 1 of acetone is added 121 g II under stirring, followed by 83 ml of dimethyl sulphate. After heating to reflux for 2 hrs, the solvent is distilled off, water is added and the mixture refluxed for a further hour. Extraction with methylene chloride and evaporation gives 125 g of crude III, which is purified by crystallization from EtOAc, m.p. 118°-120°.

1. temperatureAfter heating
2. temperatureto reflux for 2 hrs
3. distillationthe solvent is distilled off
4. additionwater is added
5. temperaturethe mixture refluxed for a further hour
6. extractionExtraction
7. customwith methylene chloride and evaporation