Benzylamine → HCID 14772862, compound

HRID 1493090Notes

Reaction equation

HRID 1493090 reaction equation
[CH3:1][N:2]([CH3:14])[C:3]1[N:4]([CH3:13])[C:5]([C:8]([O:10]CC)=O)=[N:6][N:7]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O1CCCC1>[CH2:15]([NH:22][C:8]([C:5]1[N:4]([CH3:13])[C:3]([N:2]([CH3:1])[CH3:14])=[N:7][N:6]=1)=[O:10])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 14772861HCID 14772861, compound

Product 1

HCID 14772862HCID 14772862, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6 g (0.03 mole) of ethyl 5-dimethylamino-4-methyl-4H-1,2,4-triazol-3-yl-carboxylate and 4.28 g (0.04 mole) of benzylamine are heated in 80 ml of tetrahydrofuran at 200° C. at 20 bar. For working up, the mixture is evaporated in vacuo, and the residue is purified on silica gel by means of chromatography (eluent: toluene/ethanol 1:1). 2.68 g (35% of theory) of N-benzyl-5-dimethylamino-4-methyl-4H-1,2,4-triazol-3-yl-carboxamide of melting point 96° C.-98° C. are obtained.

Workup

  1. customthe mixture is evaporated in vacuo
  2. customthe residue is purified on silica gel by means of chromatography (eluent: toluene/ethanol 1:1)

Sources & evidence

ORD record
ord-1991a96458674f4b8235b0aa3194bd9b
Source dataset
uspto-grants-1991_06
Patent number
US05021081

Reaction notes

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