2-(3,4-Dichlorophenyl)acetyl chloride → HCID 18915081, compound

HRID 1493142Notes

Reaction equation

HRID 1493142 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][O:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[CH:15]=[C:16]([CH2:21][C:22](Cl)=[O:23])[CH:17]=[CH:18][C:19]=1[Cl:20]>C(N(CC)CC)C>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]([CH2:21][C:22]([N:8]2[CH2:9][CH2:10][O:11][CH2:12][CH:7]2[CH2:6][N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:23])[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

4

Reactant 2

HCID 27581492-(3,4-Dichlorophenyl)acetyl chlorideHCID 189150613-(Pyrrolidin-1-ylmethyl)morpholine

Product 1

HCID 18915081HCID 18915081, compoundYield 53.1%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 17 was repeated, but using 1.64 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 3.72 ml of triethylamine and 1.54 g of 3,4-dichlorophenylacetyl chloride, to afford 0.72 g of the title compound, melting at 268° (dec.).

Sources & evidence

ORD record
ord-bf690fcf1d3c4d028d82b6a2d6ae4d56
Source dataset
uspto-grants-1991_06
Patent number
US05021413

Reaction notes

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