3,5-Dimethyl-1H-pyrazole-1-carboxamidine mononitrate → HCID 178483216, compound

HRID 1493182Notes

Reaction equation

HRID 1493182 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:12][N:13]([CH3:15])[CH3:14])[CH:9]=[CH:10][CH:11]=1.[N+:16]([O-:19])([OH:18])=[O:17].CC1C=C(C)[N:23]([C:27](N)=[NH:28])N=1>C(O)C>[N+:16]([O-:19])([OH:18])=[O:17].[N+:16]([O-:19])([OH:18])=[O:17].[CH3:15][N:13]([CH2:12][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=1)[O:5][CH2:4][CH2:3][CH2:2][NH:1][C:27]([NH2:28])=[NH:23])[CH3:14]

Participants

4

Reactant 2

HCID 1981863,5-Dimethyl-1H-pyrazole-1-carboxamidine mononitrateHCID 129139503-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine

Product 1

HCID 178483216HCID 178483216, compoundYield 50.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine (2 g) and 3,5-dimethylpyrazole-1-carboxamidine nitrate (2.1 g) were heated at reflux in ethanol for 16 hr. The solvent was removed and the residue was washed with boiling ethyl acetate before it was crystallised from ethanol to give the title compound as a white solid (1 g) m.p. 123°-4°.

Workup

  1. customThe solvent was removed
  2. washthe residue was washed with boiling ethyl acetate before it
  3. customwas crystallised from ethanol

Sources & evidence

ORD record
ord-888418036a134e4399e439f40c7cec00
Source dataset
uspto-grants-1991_06
Patent number
US05021429

Reaction notes

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