Methyl Isocyanate → HCID 12816954, compound

HRID 1493183Notes

Reaction equation

HRID 1493183 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]([CH2:16][N:17]([CH3:19])[CH3:18])[CH:13]=[CH:14][CH:15]=1>C(#N)C>[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][N:17]([CH3:18])[CH3:19])[CH:11]=1)=[O:4]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 129139503-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine

Product 1

HCID 12816954HCID 12816954, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Methyl isocyanate (0.27 ml) and 3-(3-aminopropoxy)-N,N-dimethylbenzenemethanamine (0.97 g) were stirred at room temperature in acetonitrile for 2 hours. The title compound was filtered off, washed with acetonitrile and recrystallised from ethyl acetate as colourless prisms (0.49 g) m.p. 79.5°-80°. TLC silica; methanol:0.88 ammonia (80:1) Rf 0.45.

Workup

  1. filtrationThe title compound was filtered off
  2. washwashed with acetonitrile
  3. customrecrystallised from ethyl acetate as colourless prisms (0.49 g) m.p. 79.5°-80°

Sources & evidence

ORD record
ord-e03fe7b5d25f432f998399aa523ef35f
Source dataset
uspto-grants-1991_06
Patent number
US05021429

Reaction notes

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